(2019) 34:185764. -, Wollina U, Chiriac A, Kocic H, Koch A, Brzezinski P. Cutaneous and hypersensitivity reactions associated with COVID19 vaccinationa narrative review. doi: 10.1111/jdv.17342, 5. Federal government websites often end in .gov or .mil. Unauthorized use of these marks is strictly prohibited. 1 Several vaccines have been developed to fight against COVID19, to prevent the transmission among susceptible individuals and to decrease the morbidity Meantime the onset, was 8.58 days, and meantime it took to recover, was 6.44 weeks. Once a person has pityriasis rosea, it rarely recurs. Polack FP, Thomas SJ, Kitchin N et al. J Eur Acad Dermatol Venereol. Cite this: Skin Reactions After COVID-19 Vaccination . National Library of Medicine 2022 Feb 3;9 (2):003164. doi: 10.12890/2022_003164. PMC Lasers Med Sci. KL and KP collated resources. doi: 10.1002/iid3.804. 10.1007/S10354-021-00876-0 Moreover, central dusky-red erythematous was observed on some plaques (Figure 2A). Ehsani AH, Nasimi M, Bigdelo Z. Pityriasis rosea as a cutaneous manifestation of COVID-19 infection. doi: 10.1111/dth.15601. Catal A, Muoz-Santos C, Galvn- Casas C, et al.. Cutaneous reactions after SARS-COV-2 vaccination: a crosssectional Spanish nationwide study of 405 cases, Pityriasis rosea-like eruption after Pfizer-BioNTech COVID-19 vaccination. doi: 10.1111/dth.13878, 10. doi: 10.1111/bjd.20143. tions reported after vaccination include: injection site reactions, urticarial and morbilliform eruptions, per-nio/chilblains, reactions to cosmetic llers, herpes zoster, herpes simplex ares, and pityriasis rosea-like rashes [1]. Dermoscopy showed dotted and linear vessels forming a network on a yellowish background, with some whitish peripheral scales (Figure 3A). Informed consent: Informed consent has been obtained. The .gov means its official. PRISMA, preferred reporting items for systematic reviews and metaanalysis. Unauthorized use of these marks is strictly prohibited. FOIA The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Book appointments online with Optimized Health and Wellness of Hudson, FL. [Epub ahead of print]. Unfortunately, due to her deteriorating neurologic status, her associated symptoms were not evaluated properly. 21% of people who have Covid develop a rash as their only symptom of infection. 2022 Jul 6;15(1):9503. doi: 10.4081/dr.2022.9503. Some patients may have a cold before the rash. doi: 10.1111/dth.15391. All patients were treated with cetirizine. Department of Dermatology, Graduate School of Medicine, Kyusyu University, Japan. HHS Vulnerability Disclosure, Help doi: 10.1111/dth.13650, 7. Rashes show as hives, bumps or . Cutaneous reactions reported after Moderna and Pfizer COVID-19 vaccination: A registry-based study of 414 cases. Viruses, Variants, and Vaccines: How COVID-19 Has Changed the Way We Look at Skin. -, Johansen M, Chisolm SS, Aspey LD, Brahmbhatt M. Pityriasis rosea in otherwise asymptomatic confirmed COVID-19-positive patients: a report of 2 cases. It is believed to represent a delayed reaction to viral infections and is usually associated with endogenous systemic reactivation of human herpesvirus (HHV) 6 and / or 7 (1). doi: 10.1016/j.jaad.2020.04.094, 8. This table includes information on vaccines that have published phase 3 trial data in the peer reviewed literature and are provisionally approved by the Australian Government Therapeutic Goods Administration (TGA). Then you may get smaller spots that sweep out from the middle of the body in a shape that looks like drooping pine-tree branches. Dursun R, Temiz SA. (a) Pityriasis rosea (chest, flank, and axilla); (b) pityriasis rosea (back). Chanprapaph K, Pomsoong C, Tankunakorn J, Eden C, Suchonwanit P, Rutnin S. Comparative analyses of clinical features, histopathology, and CD123 immunohistochemistry of oral lupus erythematosus, lichen planus, and other lichenoid lesions. doi: 10.1111/dth.15129. Cutis. PRISMA, preferred reporting items for systematic reviews and metaanalysis. Post Covid-19 vaccination papulovesicular pityriasis rosea-like eruption in a young male. 2022 Jul 6;15(1):9503. doi: 10.4081/dr.2022.9503. 8600 Rockville Pike She was prescribed outpatient COVID-19 treatment of azithromycin, vitamins D and C, and then quarantined for 2 weeks. The .gov means its official. The clinics of HHV-6 infection in COVID-19 pandemic: pityriasis rosea and Kawasaki disease. A 3-cm oval plaque with peripheral scale, larger than the other lesions, was present on the inferior portion of the right breast. McMahon DE, Amerson E, Rosenbach M, Lipoff JB, Moustafa D, Tyagi A, Desai SR, French LE, Lim HW, Thiers BH, Hruza GJ, Blumenthal KG, Fox LP, Freeman EE. 8600 Rockville Pike PR is a self-limiting exanthematous disease and herpes zoster is a treatable condition; therefore, their occurrence does not require discontinuation of the vaccination schedule. A Yale-led study published in the journal Immunity in May offers a few theories on why some children develop MIS-C and others don't. Mohta A, Mohta A, Ghiya BC, Mehta RD, Kumar V. Indian J Dermatol. doi: 10.12998/wjcc.v5.i6.203, 6. The face may be involved; involvement of the oral cavity occurs in 50% of patients. Thirty-one studies were included for data extraction after screening following the eligibility criteria. The https:// ensures that you are connecting to the The authors declare no conflict of interest. Dermatol Reports. Few brownish patches also appeared, suggestive of post-inflammatory hyperpigmentation. In addition to reactivation of HHV-6 or HHV-7, PR can be triggered by some drugs (like angiotensin-converting enzyme inhibitors alone or in combination with hydrochlorothiazide, sartans plus hydrochlorothiazide, allopurinol, nimesulide, and acetyl salicylic acid (2) and vaccines (such as smallpox, poliomyelitis, influenza, human papillomavirus, diphtheria, tuberculosis, hepatitis B, pneumococcus, and yellow fever vaccines) (3). J Med Virol 2021; 93: 1850-1851. Moreover, almost all lesions faded with associated post-inflammatory hyperpigmentation (Figure 2B). Br J Dermatol. eCollection 2023 Mar-Apr. Suchonwanit P, Triamchaisri S, Wittayakornrerk S, Rattanakaemakorn P. Leprosy Reaction in Thai Population: A 20-Year Retrospective Study. Received 2022 Mar 26; Accepted 2022 Apr 25. Careers. official website and that any information you provide is encrypted Ethical review and approval was not required for the study on human participants in accordance with the local legislation and institutional requirements. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Abstract Dear Editor, Pityriasis rosea (PR) is a common, self-limited erythematous papulosquamous dermatosis that mainly affects young adults. Pityriasis rosea is a common viral infection that usually affects individuals between 10-35 years of age. Please enable it to take advantage of the complete set of features! -, Welsh E, Cardenas-de la Garza JA, Cuellar-Barboza A, Franco-Marquez R, Arvizu-Rivera RI. The .gov means its official. J Eur Acad Dermatol Venereol 2016; 30: 544-545. The ones found in people with pityriasis rosea are human herpesviruses 6 and 7. (2016) 30:5445. Unlike in our patient, oropharyngeal lesions were observed in approximately 16% of patients with typical PR (10). 2022 Nov-Dec;67(6):802-804. doi: 10.4103/ijd.ijd_562_22. However, in cases of atypical PR, it may present with erythema multiforme-like lesions and purpura (5). It can take 1 to 3 months to go away. doi: 10.1111/ijd.15700, 4. See this image and copyright information in PMC. As previously mentioned, only some cases of PR/PRLE after anti-SARS-CoV-2 vaccination have been reported (Table 2).1-18, PRLE usually appears following a drug, without prodromal symptoms. 2021;184(6):11941195. The advent of vaccines has drastically reduced the incidence, morbidity, and mortality related to COVID-19 [1]. 8600 Rockville Pike Keywords: All patients were treated with cetirizine (20 mg/day for 7-14 days). Although histopathologic characteristics of PR are also observed in PR-like lesions, the presence of dyskeratotic keratinocytes, interface dermatitis, and eosinophilic infiltration in the dermis may be more prominent in PR-like eruptions (11). Suchonwanit P, Hector CE, Bin Saif GA, McMichael AJ. Temiz SA, Abdelmaksoud A, Dursun R, Durmaz K, Sadoughifar R, Hasan A. J Cosmet Dermatol. Pityriasis Rosea-like eruptions following COVID-19 mRNA-1273 vaccination: A case report and literature review. Pityriasis rosea and pityriasis rosea-like eruption after anti-SARS-CoV-2 vaccination: a report of five cases and review of the literature. Of the 30 cases found, none experienced severe adverse effects and the rash resolved in an average of 5.6 weeks. sharing sensitive information, make sure youre on a federal official website and that any information you provide is encrypted reactions included pernio/chilblains, cosmetic ller reactions, zoster, herpes simplex ares, and pityriasis rosea-like reactions. A history of viral infection preceding the disease was reported Clin Dermatol. J Am Acad Dermatol. 2021 Dec;108(6):317-318. doi: 10.12788/cutis.0411. and transmitted securely. Suchonwanit P, Rojhirunsakool S, Khunkhet S. A randomized, investigator-blinded, controlled, split-scalp study of the efficacy and safety of a 1550-nm fractional erbium-glass laser, used in combination with topical 5% minoxidil versus 5% minoxidil alone, for the treatment of androgenetic alopecia. To the best of our knowledge, only one case of ChAdOx1 nCoV-19 vaccine-induced PR-like eruption has been reported (2). 2022 Jun;7:164-168. doi: 10.1016/j.jdin.2022.01.009. In all patients laboratory examinations were within normal ranges. The length of the rash is shorter in comparison with PR.19. J Formos Med Assoc. Histopathologic features: (B) microscopic image at a low power field showing psoriasiform epidermal hyperplasia, perivascular infiltration, and interface dermatitis (hematoxylin-eosin; scale bar represents 100 m); (C) microscopic image at a high power field showing focal spongiotic dermatitis, interface dermatitis, and perivascular infiltration of lymphocytes and eosinophils (hematoxylin-eosin; scale bar represents 40 m). FOIA Numerous scattered erythematous plaques with fine scale oriented along skin cleavage lines, most appreciable on the upper portion of the chest. Pityriasis versicolor is caused by a yeast infection and can be treated with antifungal medicines , including antifungal creams and antifungal shampoos. Unauthorized use of these marks is strictly prohibited. Bethesda, MD 20894, Web Policies All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Veraldi S, Boneschi V, Cusini M, Maronese CA. NCI CPTC Antibody Characterization Program, Ritchie H., Mathieu E., Rodes-Guirao L., et al. The third type of rash, known as Covid fingers and toes (sometimes described as chilblains), is where red and purple bumps appear on the fingers or toes.. Busto-Leis JM, Servera-Negre G, Mayor-Ibarguren A, et al.. Pityriasis rosea, COVID-19 and vaccination: new keys to understand an old acquaintance, Pityriasis rosea following CoronaVac COVID-19 vaccination: a case report, Pityriasis rosea after administration of Pfizer-BioNTech COVID-19 vaccine. Authors Jordan E Buckley 1 , Laura N Landis 2 , Ronald P Rapini 1 Affiliations SARS-CoV-2 vaccine; cutaneous side-effects; infection; papulosquamous; skin diseases; vaccine hesitancy. 2023 The Authors. Pityriasis rosea, COVID-19 and vaccination: new keys to understand an old acquaintance. We include a review on all cases of PR/PRLE after anti- SARS-CoV-2 vaccination reported in the literature and discuss some pathogenetic hypotheses. Unable to load your collection due to an error, Unable to load your delegates due to an error. Variable dermatological manifestations including acral erythema, urticaria, vasculitis, vesicular or pustular eruptions, maculopapular rash have all been reported during the course of COVID19. doi: 10.1111/dth.15602. -, Cyrenne BM, Al-Mohammedi F, DeKoven JG, Alhusayen R. Pityriasis rosea-like eruptions following vaccination with BNT162b2 mRNA COVID-19 vaccine. Disclaimer. National Library of Medicine Pityriasis rosea developing after COVID-19 vaccination. Epub 2021 Nov 2. 2022 Nov 1;43(6):555-558. doi: 10.2500/aap.2022.43.220058. Unauthorized use of these marks is strictly prohibited. Wien Med Wochenschr. Martora F, Battista T, Marasca C, Genco L, Fabbrocini G, Potestio L. Clin Cosmet Investig Dermatol. However, several adverse effects of COVID-19 vaccination have been identified. Careers. Leerunyakul K, Pakornphadungsit K, Suchonwanit P. Front Med (Lausanne). Pityriasis rosea-like eruption presenting as multiple discrete erythematous oval patches and plaques on the back (A) lower abdomen, and bilateral upper thighs (B); lesions distributed along cleavage lines without prominent scales (C). These findings were consistent with a diagnosis of PR-like eruption. government site. The rash typically lasts 6-9 weeks, rarely extending longer than 12 weeks. In 4 patients PR appeared after the first vaccination; in one patient after the second one. SARS-CoV-2 spike protein positivity in pityriasis rosea-like and urticaria-like rashes of COVID-19. Drago F, Broccolo F, Ciccarese G. Pityriasis rosea, pityriasis rosea-like eruptions, and herpes zoster in the setting of COVID-19 and COVID-19 vaccination. Scleroderma or CREST syndrome is a chronic, auto immune disease which manifests as. Before 2021 Nov;35(11):e721-e722. Before Pityriasis Rosea-like eruptions following COVID-19 mRNA-1273 vaccination: A case report and literature review. NS, not specified; PR, pityriasis rosea; PRL, pityriasis rosea-like. Would you like email updates of new search results? doi: 10.1111/jdv.12942, 13. PMC Accessibility Drago F, Ciccarese G, Rebora A, et al. Would you like email updates of new search results? Would you like email updates of new search results? Clipboard, Search History, and several other advanced features are temporarily unavailable. Pityriasis rosea is a type of skin rash. Epub 2021 Aug 26. MeSH All patients are currently in good general health. Common causes of drug-induced PR-like eruptions include angiotensin-converting enzyme inhibitors, non-steroidal anti-inflammatory drugs, and gold. Due to the temporal relationship between vaccination and onset of rash, COVID-19 vaccination was the most likely etiology. Herald patch is often absent. COVID-19 vaccine hesitancy is a critical problem that hinders Pityriasis Rosea Associated With COVID-19 Vaccination: A Common Rash Following Administration of a Novel Vaccine. Many Americans become infected with them at an early age. -, Rasheed R, Rizwan A, Javed H, Sharif F, Zaidi A. Socioeconomic and environmental impacts of COVID19 pandemic in Pakistanan integrated analysis. The .gov means its official. In one small study, a majority of women who got pityriasis rosea in . Manifestation of pityriasis rosea and pityriasis rosea-like eruptions after Covid-19 vaccine: A systematic review. pityriasis rosea after covid vaccine Last month at Barret-jackson in Scottsdale, Arizona a 1929 Roadster was put up for sale by Dave Kindig of . Authors Elina Khattab 1 , Eirini Christaki 2 , Constantinos Pitsios 1 Affiliations 1 Medical School, University of Cyprus, Nicosia, Cyprus. Pityriasis is linked mainly with herpesviruses 6 and 7; only a small number of cases have been reported in association with vaccinations (e.g., yellow fever, influenza, hepatitis B, human. Int J Infect Dis. Vaccine-Related Eruptions of Papules and Plaques Following COVID-19 Vaccination - A Case Series. It is updated regularly. Moreover, while dermoscopy may facilitate the diagnosis of PR, its utility for atypical PR or PR-like lesions is still limited. The following self-care tips may help relieve the discomfort of pityriasis rosea: Take nonprescription allergy medicine (antihistamines), such as diphenhydramine (Benadryl, others). Br J Dermatol. Would you like email updates of new search results? Pityriasis rosea and pityriasis rosea-like eruption after anti-SARS-CoV-2 vaccination: a report of five cases and review of the literature. The condition is more prevalent in spring and fall. Methods: With COVID-19 vaccines being authorized for emergency use, monitoring for potential adverse effects (e.g., cutaneous reactions) is necessary. Dermatol Ther. Pityriasis rosea (PR) is an acute, exanthematous disease likely caused by human herpesvirus (HHV)-6 and/or HHV-7. 2021;35(8):e489e491. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). -, Broccolo F., Drago F., Careddu A.M., et al. Clipboard, Search History, and several other advanced features are temporarily unavailable. Pityriasis rosea, pityriasis rosea-like eruptions, and herpes zoster in the setting of COVID-19 and COVID-19 vaccination. official website and that any information you provide is encrypted Here, we described a case of PR-like eruption that developed 14 days after Oxford/AstraZeneca vaccination in a 52-year-old Thai woman with glioblastoma. and transmitted securely. Results were superimposable: parakeratosis, mild spongiosis, acanthosis and exocytosis were seen in the epidermis. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). 2022 Aug;35(8):e15601. Veraldi S, Boneschi V, Cusini M, Maronese CA. COVID-19; HHV, human herpes virus; Moderna; PR; PR, pityriasis rosea; PR-LE; PR-LE, pityriasis rosea-like eruption; Pfizer; coronavirus; dermatology; mRNA vaccine; mRNA, messenger RNA; pityriasis rosea; pityriasis rosealike eruption; vaccine. Leerunyakul K, Pakornphadungsit K, Suchonwanit P. Case report: pityriasis rosea-like eruption following COVID- 19 vaccination. The SARSCoV2 pandemic plagued the world over the course of the year. But once it's gone, it doesn't come back. This is called the herald patch. Veraldi S, Boneschi V, Cusini M, Maronese CA.