Treatment failure and excess mortality were observed when BACTRIM was used concomitantly with leucovorin for the treatment of HIV positive patients with Pneumocystis jirovecii pneumonia in a randomized placebo controlled trial.4 Avoid coadministration of BACTRIM and leucovorin during treatment of Pneumocystis jirovecii pneumonia. information highlighted below and resubmit the form. FOIA DOI: Mekaru S. (2011). Sulfamethoxazole and trimethoprim combination is used to treat infections including urinary tract infections, middle ear infections (otitis media), bronchitis, traveler's diarrhea, and shigellosis (bacillary dysentery). (2017). Akande M, Audino AN, Tobias JD. 5. This list is not complete and many other drugs may interact with sulfamethoxazole and trimethoprim. Sulfamethoxazole and trimethoprim are are both antibiotics that treat different types of infection caused by bacteria. The popularity of tattoos may convince you that they arent all that risky to get. When this happens, other conditions can develop, such as sepsis, arthritis, and toxic shock syndrome. Fatalities associated with the administration of sulfonamides, have occurred due to severe reactions, including, Stevens-Johnson Syndrome, toxic epidermal necrolysis, fulminant hepatic necrosis, agranulocytosis, aplastic anemia and other blood dyscrasias. Clinical studies have documented that patients with group A -hemolytic streptococcal tonsillopharyngitis have a greater incidence of bacteriologic failure when treated with BACTRIM than do those patients treated with penicillin, as evidenced by failure to eradicate this organism from the tonsillopharyngeal area. Sulfamethoxazole alone was positive in an in vitro reverse mutation bacterial assay and in in vitro micronucleus assays using cultured human lymphocytes. In vitro studies suggest that trimethoprim is a substrate of P-glycoprotein, OCT1 and OCT2, and that sulfamethoxazole is not a substrate of P-glycoprotein. These steady-state levels were achieved after three days of drug administration. Amber Yates, MD, is a board-certified pediatric hematologist and a practicing physician at Baylor College of Medicine. Weighing 16 kg2 teaspoonfuls (10 mL) or 1 tablet 4 times a day for 14 to 21 days. Peritoneal dialysis is not effective and hemodialysis is only moderately effective in eliminating trimethoprim and sulfamethoxazole. Buy Bactrim Pills Online - Sulfamethoxazole Nunc pellentesque Bactrim (co-trimoxazole) is typically recommended for patients diagnosed with microbial infections. The patient was treated with a 2-month course of oral trimethoprim-sulfamethoxazole (160mg/800mg twice daily) and ciprofloxacin (250 mg twice daily), with clinical improvement at follow up after three weeks of the antibiotic regimen. 1998-2023 Mayo Foundation for Medical Education and Research (MFMER). Like other drugs containing sulfonamides, BACTRIM can precipitate porphyria crisis and hypothyroidism. The mean maximum serum trimethoprim concentration was higher and mean renal clearance of trimethoprim was lower in geriatric subjects compared with younger subjects [see CLINICAL PHARMACOLOGY]. Sulfonamides, including sulfonamide-containing products such as BACTRIM, should be discontinued at the first appearance of skin rash or any sign of adverse reaction. (n.d.), statista.com/chart/9980/us-adults-with-a-tattoo/, fda.gov/consumers/consumer-updates/tattoo-you-seven-key-questions-consider, smithsonianmag.com/smart-news/how-common-are-infections-from-tattoo-ink-32664291/, ouh.nhs.uk/patient-guide/leaflets/files/33184Pmicropigmentation.pdf, ncbi.nlm.nih.gov/pmc/articles/PMC4411590/, diseasedaily.org/diseasedaily/article/cdc-links-rare-bacterial-infection-tattoos-81211, cdc.gov/mmwr/preview/mmwrhtml/mm5524a3.htm, dermnetnz.org/topics/tattoo-associated-skin-reactions/, prnewswire.com/news-releases/one-in-five-us-adults-now-has-a-tattoo-140123523.html, health.harvard.edu/blog/tattoos-and-infection-think-before-you-ink-201210125405, cdc.gov/mmwr/preview/mmwrhtml/mm6133a3.htm, blogs.cdc.gov/publichealthmatters/2012/08/the-hidden-dangers-of-getting-inked/, fda.gov/consumers/consumer-updates/think-you-ink-are-tattoos-safe, patient.uwhealth.org/education/after-care-instructions-for-permanent-tattooing.html, Help! Arch Dis Child. Alternatively, other epidemiologic studies did not detect statistically significant associations between BACTRIM exposure and specific malformations. How common are infections from tattoo ink? If they didnt provide you with clear guidelines afterward, give them a call. Oct 1988;44(4):467-77. Suvanasuthi S, Wongpraparut C, Pattanaprichakul P, Bunyaratavej S. Nagore E, Ramos P, Botella-Estrada R, Ramos-Nguez JA, Sanmartn O, Castejn P. Acta Derm Venereol. Oral isotretinoin for acne. Weighing 48 kg6 teaspoonfuls (30 mL) or 3 tablets (or 1 DS tablets) 4 times a day for 14 to 21 days. Did you know that favism is another term for G6PD deficiency, especially in severe cases? 2015 Jun 16;21(6):13030/qt8mr3r4f0. Avoid sunlight or tanning beds. Fortunately, many people with G6PD deficiency can tolerate other malaria medications. He denied similar symptoms with previous tattoos. Active against a wide range of susceptible strains of gram-positive and gram-negative bacteria, such as. 8600 Rockville Pike Tattoo ink-related infections Awareness, diagnosis, reporting, and prevention. Propylene glycol toxicity can lead to acute kidney injury, CNS toxicity, and multi-organ failure. Amber Yates, MD, is a board-certified pediatric hematologist and a practicing physician at Baylor College of Medicine. May not be suitable for some people including those with kidney or liver disease, folate deficiency (the elderly, chronic alcoholics, and people taking anticonvulsants are at risk of folate deficiency), glucose-6-phosphate deficiency, porphyria, severe allergies, thyroid dysfunction, or bronchial asthma. The site is secure. Patients who are slow acetylators may be more prone to idiosyncratic reactions to sulfonamides. Since there has been no extensive experience in humans with single doses of BACTRIM in excess of 25 mL (400 mg trimethoprim and 2000 mg sulfamethoxazole), the maximum tolerated dose in humans is unknown. Now, you're probably thinking it might not matterplus, it's your personal information, why do they need to know? Margassery S, Bastani B. If you're not sure, asking never hurts! Its your health! Last medically reviewed on June 10, 2021. If you're not disclosing your medical conditions to your tattoo artist prior to your session, what your tattoo artist doesn't know could seriously harm you. J Ophthalmic Inflamm Infect. BACTRIM is available as an injection containing 80 mg/mL of sulfamethoxazole and 16 mg/mL of trimethoprim in 10 mL single-dose and 30 mL multiple-dose vials. Glucose-6-phosphate dehydrogenase (G6PD)deficiency is a genetic condition that can be passed down from parents to their children. Because these reactions were reported voluntarily from a population of uncertain size, it is not possible to reliably estimate their frequency or establish a causal relationship to drug exposure: Trimethoprim is an inhibitor of CYP2C8 as well as OCT2 transporter. J Pediatr Pharmacol Ther. Hence, there is potential for an additive myelotoxicity when coadministered. Seven key questions to consider. Patients with renal dysfunction, liver disease, malnutrition or those receiving high doses of BACTRIM are particularly at risk. You'll soon start receiving the latest Mayo Clinic health information you requested in your inbox. antidepressants, such as amitriptyline, amoxapine, and desipramine, anticoagulants (blood thinners), such as warfarin, blood pressure medications, such as captopril or enalapril, medications that affect the nervous system, such as amantadine or memantine, other medications that may inhibit or induce CYP2D6 enzymes, Bactrim (sulfamethoxazole and trimethoprim) [Package Insert]. The combination of sulfamethoxazole/trimethoprim is bactericidal (kills bacteria). To establish that the product manufacturers addressed safety and efficacy standards, we: We do the research so you can find trusted products for your health and wellness. The antibiotics didn't effect the healing process, or how it looked after it healed, like I was worried about. May lower blood sugar levels in people without diabetes. Anecdotally, some people have reported unusual skin reactions to tattoos when they were on antibiotics. 12. information highlighted below and resubmit the form. This practice includes employing preventative measures like wearing gloves and other protective gear and extends to avoiding contact with the client's body fluids. Urine concentrations of both trimethoprim and sulfamethoxazole are considerably higher than are the concentrations in the blood. If these occur the infusion should be discontinued and restarted at another site. information submitted for this request. No interference occurs, however, if methotrexate is measured by a radioimmunoassay (RIA). If you have a condition like these, it's understandable to worry that disclosing it to your artist might result in being refused service. The incidence of congenital abnormalities was 4.5% (3 of 66) in those who received placebo and 3.3% (4 of 120) in those receiving trimethoprim and sulfamethoxazole. Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use bactrim only for the indication prescribed. Healthline Media does not provide medical advice, diagnosis, or treatment. The sulfamethoxazole component belongs to the class of medicines known as sulfonamides, and the trimethoprim component belongs to the class of medicines known as folic acid inhibitors. Drug class: Sulfonamides. Trimethoprim, component of BACTRIM, has been noted to impair phenylalanine metabolism, but this is of no significance in phenylketonuric patients on appropriate dietary restriction. However, though rare, its possible to get a condition such as hepatitis or HIV from a tattoo needle. When renal function is impaired, a reduced dosage should be employed, as shown in Table 2. The pharmacokinetics of sulfamethoxazole 800 mg and trimethoprim 160 mg were studied in six geriatric subjects (mean age: 78.6 years) and six young healthy subjects (mean age: 29.3 years) using a non-US approved formulation. She has been an amateur artist as a hobby since grade school, and served a 12 month tattoo apprenticeship in a tattoo studio. This content does not have an English version. BACTRIM is contraindicated in the following: BACTRIM is an antimicrobial drug [see Microbiology]. Sulfamethoxazole inhibits bacterial synthesis of dihydrofolic acid by competing with para-aminobenzoic acid (PABA). Monitor patients for hematologic toxicity. If a dilution of 5 mL per 100 mL of 5% dextrose in water is desired, it should be used within 4 hours. Staph infections are also common on fresh tattoos and may start showing signs as soon as after 2 days. Antibiotic medicines can cause diarrhea. Seek medical treatment if you have a serious drug reaction that can affect many parts of your body. Prescription drugs for acne can cause skin to be hyper-sensitive. nausea. Other things to consider before getting a tattoo include: If your tattoo artist gave you instructions on how to take care of your tattoo, follow those instructions closely. BACTRIM must be diluted. Copyright 1996-2023 Drugs.com. It seemed to be missing beats and stopping at times. Accessibility Discontinue BACTRIM if propylene glycol toxicity is suspected [see ADVERSE REACTIONS]. Advise nursing women to avoid breastfeeding during treatment with BACTRIM. BACTRIM (sulfamethoxazole and trimethoprim) injection is supplied as follows: 10-mL Vials, containing 160 mg trimethoprim (16 mg/mL) and 800 mg sulfamethoxazole (80 mg/mL) for infusion with 5% dextrose in water. This requires long-term antibiotic treatment. Drug information provided by: Merative, Micromedex. privacy practices. Created for people with ongoing healthcare needs but benefits everyone. Kluger N. Contraindications for tattooing. Consult with your doctor first to determine if your overall health is strong enough to withstand the stress of getting tattooed and if your medications may interfere with the healing process. Rasburicase-induced hemolytic anemia in an adolescent with unknown glucose-6-phosphate dehydrogenase deficiency. Last reviewed on RxList: 11/25/2020 Repeat these steps about 4 times a day for at least 4 days. The minimum amount of benzyl alcohol at which serious adverse reactions may occur is not known [see WARNINGS AND PRECAUTIONS]. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. BACTRIM contains propylene glycol as a solvent (40% v/v). It is a white to light yellow, odorless, bitter compound with a molecular weight of 290.3 and the following structural formula: Sulfamethoxazole is N1-(5-methyl-3-isoxazolyl) sulfanilamide. Follow your doctor's orders or the directions on the label. Transformations: After-care instructions for permanent tattooing. Ask your healthcare professional how you should dispose of any medicine you do not use. Brand names: Bactrim, Bactrim DS Around 4 in 10 Americans now have one or more tattoos. MRSA skin infection signs and symptoms. How Can You Increase Your Red Blood Cells? You'll soon start receiving the latest Mayo Clinic health information you requested in your inbox. Many people with G6PD deficiency don't experience any symptoms at all on a daily basis. Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Bactrim only for the indication prescribed. Mar 1979;15:447-451. Federal government websites often end in .gov or .mil. All rights reserved. You have to notify your physician prescribing you Bactrim of the reality of planning or taking on taking seizure medicines, diuretics, methotrexate, blood slimmers, or ACE inhibitors. Bactrim stops the growth of certain types of bacteria that cause infections. At least 90 percent of the following bacteria exhibit an in vitro minimum inhibitory concentration (MIC) less than or equal to the susceptible breakpoint for BACTRIM against isolates of similar genus or organism group. Also, although an artist has the right to refuse service to a potential client based on health reasons, you also have the right to take your business elsewhere if you feel the artist was in error or being unfair. Tattoo infections are usually easy to treat and even easier to prevent. The Best Online Dermatologists to Treat Your Skin, Tattoo Placement 101: The Ultimate Guide, From Pain Level to Healing Time, Spironolactone for Acne: What You Need to Know Before Use. The incidence of adverse reactions, particularly rash, fever, leukopenia, and elevated aminotransferase (transaminase) values, with BACTRIM therapy in AIDS patients who are being treated for Pneumocystis jirovecii pneumonia has been reported to be greatly increased compared with the incidence normally associated with the use of BACTRIM in non-AIDS patients. The hidden dangers of getting inked. You should also see a doctor if you experience uncomfortable itching around the tattooed area or if the area is oozing pus or fluid. Bactrim pregnancy and breastfeeding warnings. Dr. Hiep Le answered Nephrology and Dialysis 44 years experience The base PPD is colourless and requires oxygen for it to become a dye, thus PPD hair dyes . Simple infections confined to the skin and underlying superficial soft tissues generally respond well to outpatient management. Clinical signs, such as rash, sore throat, fever, arthralgia, cough, shortness of breath, pallor, purpura or jaundice may be early indications of serious reactions. View complete list of side effects. Available for Android and iOS devices. There were no abnormalities in the 10 children whose mothers received the drug during the first trimester. This is not a complete list of side effects and others may occur. You should not use Bactrim if you have severe liver disease, kidney disease that is not being monitored, anemia caused by folic acid deficiency, if you take dofetilide, or if you have had low platelets caused by using trimethoprim or a sulfa drug. J Infect Dis. Probably not. A skin rash may be followed by more severe reactions, such as Stevens-Johnson syndrome, toxic epidermal necrolysis, hepatic necrosis or serious blood disorder. We comply with the HONcode standard for trustworthy health information. Byrdie takes every opportunity to use high-quality sources, including peer-reviewed studies, to support the facts within our articles. Aquaphor is a product that tattoo artists often recommend to be used on new tattoos during aftercare. Al-Khatib SM, LaPointe N, Kramer JM, Califf RM. They are often used to treat urinary tract infections (UTIs) and pneumonia in adults. Go to the emergency room right away if this kind of allergic reaction occurs. Seek urgent medical advice if an unexplained cough, shortness of breath, sore throat, fever, muscle or joint pain, paleness or yellowing of the skin, or diarrhea develops. As with any skin infection, in severe cases bacteria can enter your bloodstream and actually become life-threatening." Keep in mind, tattoo infections are usually deeper in the skin as the needle. Septra and Bactrim (sulfamethoxazole-trimethoprim) are some common brand names you might encounter. and transmitted securely. Tattoo-associated skin reactions. This can cause the area to heal improperly, which may make you more susceptible to infections. Anna Harris is an experienced fact-checker and researcher and a beauty writer and editor. Discontinuation of BACTRIM treatment is recommended to help lower potassium serum levels. 30-mL Multiple-dose Vials, each 5 mL containing 80 mg trimethoprim (16 mg/mL) and 400 mg sulfamethoxazole (80 mg/mL) for infusion with 5% dextrose in water. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Antivir Ther. In the literature, three cases of hyperkalemia in elderly patients have been reported after concomitant intake of BACTRIM and an angiotensin converting enzyme inhibitor. Review/update the Getting a tattoo from a person or a shop that doesnt properly clean their tools or provide you with instructions for keeping your fresh tattoo clean can lead to skin conditions, infections, or other health problems. BACTRIM is contraindicated in pediatric patients less than two months of age [see CONTRAINDICATIONS]. Pneumocystis jirovecii Pneumonia (1.1) Shigellosis (1.2) The presence of 10 mg percent sulfamethoxazole in plasma decreases the protein binding of trimethoprim by an insignificant degree; trimethoprim does not influence the protein binding of sulfamethoxazole. health information, we will treat all of that information as protected health Additional adverse reactions included gradual neurological deterioration, seizures, intracranial hemorrhage, hematologic abnormalities, skin breakdown, hepatic and renal failure, hypotension, bradycardia, and cardiovascular collapse. June 1980;92:762-769. The most common adverse reactions are gastrointestinal disturbances (nausea, vomiting, and anorexia) and allergic skin reactions (such as rash and urticaria). In the U.S. general population, the estimated background risk of major birth defects and miscarriage in clinically recognized pregnancies is 2% to 4% and 15% to 20%, respectively. Weighing 24 kg3 teaspoonfuls (15 mL) or 1 tablets 4 times a day for 14 to 21 days. These studies, however, were limited by the small number of exposed cases and the lack of adjustment for multiple statistical comparisons and confounders. Bactrim will not treat viral infections, such as a cold, or some bacterial infections such as those caused by streptococcal bacteria. Bookshelf Prescribing BACTRIM in the absence of a proven or strongly suspected bacterial infection or a prophylactic indication is unlikely to provide benefit to the patient and increases the risk of the development of drug-resistant bacteria. The presence of BACTRIM may also interfere with the Jaffe alkaline picrate reaction assay for creatinine, resulting in overestimations of about 10% in the range of normal values. What Are The Reasons Not to Get a Tattoo? 1999;45:209- 212. When prescribing BACTRIM in pediatric patients (two months of age and older), consider the combined daily metabolic load of benzyl alcohol from all sources including BACTRIM (contains 10 mg of benzyl alcohol per mL) and other drugs containing benzyl alcohol. Tell your doctor about all your current medicines. Antibiotics: Disclose all antibiotics to your tattoo artist, and . All of these 11 patients had normal renal function, and their ages ranged from 17 to 78 years (median, 60 years).11, Pharmacokinetic studies in children and adults suggest an age-dependent half-life of trimethoprim, as indicated in Table 5.12, Table 5: Half-life of Trimethoprim (TMP) in Pediatric Patients and Adults. Portions of this document last updated: Feb. 01, 2023. Mothballs contain a chemical called naphthalene. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. sore throat. Trimethoprim blocks the production of tetrahydrofolic acid from dihydrofolic acid by binding to and reversibly inhibiting the required enzyme, dihydrofolate reductase. This product is available in the following dosage forms: There is a problem with sores, ulcers, or white spots in the mouth or on the lips. Reddit and its partners use cookies and similar technologies to provide you with a better experience. Discover the health risks associated with tattoos and piercings, tips for having a safe procedure, and, New research highlights the lack of oversight and regulation regarding the production of tattoo ink in the US and suggests some ingredients may carry, After getting a new tattoo, the outer layer of skin will typically appear healed within 2 to 3 weeks. 2005;10(5):615-24. BMJ Case Rep. 2017;2017:bcr2017220483. Weighing 40 kilograms (kg)4 teaspoonfuls (20 mL) of oral liquid or 2 tablets (or 1 DS tablet) 2 times a day for 10 days. How well a drug is distributed throughout your body. Glucose-6-phosphate dehydrogenase deficiency. The risk of side effects may be higher in the elderly. Both trimethoprim and sulfamethoxazole distribute to sputum and vaginal fluid; trimethoprim also distributes to bronchial secretions, and both pass the placental barrier and are excreted in breast milk. May interact with several other drugs including thiazides, warfarin, phenytoin, leucovorin, methotrexate, digoxin, and medications for diabetes. In glucose-6-phosphate dehydrogenase deficient individuals, hemolysis may occur. Have tattoos or body piercing . Think before you ink: Are tattoos safe? the unsubscribe link in the e-mail. This content does not have an Arabic version. They both are antibiotics used to treat a variety of bacterial infections. It is an almost white, odorless, tasteless compound with a molecular weight of 253.28 and the following structural formula: BACTRIM is indicated in the treatment of Pneumocystis jirovecii pneumonia in adults and pediatric patients two months of age and older. To reduce the development of drug-resistant bacteria and maintain the effectiveness of Bactrim (sulfamethoxazole and trimethoprim) tablets and other antibacterial drugs, Bactrim (sulfamethoxazole and trimethoprim) tablets should be used only to treat or prevent infections that are proven or strongly . CDC links rare bacterial infection to tattoos. These effects are reversible by folinic acid therapy [see Use In Specific Populations]. Don't go to someone you know uses unsafe practices because nobody safe will give you one. If you begin to feel feverish and experience abnormal oozing or scabbing around the tattooed area, see a doctor. Pharmacology of Intravenous Trimethoprim-Sulfamethoxazole in Children and Adults. (2012). Speak to your doctor about how drug interactions should be managed. They can let you know whether the medications are safe to take with G6PD deficiency. Nausea, vomiting, abdominal pain, diarrhea, mouth or tongue inflammation, weight loss, flatulence, rash, and itchy skin. For patients taking the oral liquid, use a specially marked measuring spoon or other device to measure each dose accurately. Use of BACTRIM at high doses and/or for extended periods of time may cause bone marrow depression manifested as thrombocytopenia, leukopenia and/or megaloblastic anemia. 3. 2018;11(11):CD009435. Universal precautions for preventing transmission of bloodborne infections. Cochrane Database Syst Rev. All rights reserved. Likewise, fava beans have a similar reaction and are best to avoid as well. Children 2 months of age and olderDose is based on body size and must be determined by your doctor. red, irritated eyes. If CDAD is suspected or confirmed, ongoing antibacterial use not directed against C. difficile may need to be discontinued. To make sure you can safely take Bactrim, tell your doctor if you have ever had: an electrolyte imbalance (such as low blood sodium or high potassium); porphyria, or glucose-6-phosphate dehydrogenase (G6PD) deficiency; or. Avoid use of BACTRIM in patients with impaired renal or hepatic function, in those with possible folate deficiency (e.g., the elderly, chronic alcoholics, patients receiving anticonvulsant therapy, patients with malabsorption syndrome, and patients in malnutrition states) and in those with severe allergies or bronchial asthma. Bad infections may result in long-term antibiotic care, but usually they wont cause any long-lasting health problems. Even treatment with recommended doses may cause hyperkalemia when trimethoprim is administered to patients with underlying disorders of potassium metabolism, with renal insufficiency, or if drugs known to induce hyperkalemia are given concomitantly. Because of the potential risk of bilirubin displacement and kernicterus on the breastfed child [see CONTRAINDICATIONS], advise women to avoid breastfeeding during treatment with BACTRIM. Acute cellulitis and erysipelas in adults: Treatment. Histopathologic examination revealed perifollicular chronic and granulomatous inflammation, consistent with chronic folliculitis. So you could be exposed to the chemical by inhaling the vapor or ingesting products that contain it. People with G6PD deficiency can tolerate most antibiotics. (875 mg orally every 12 hours) plus either doxycycline (100 mg orally twice daily) or trimethoprim-sulfamethoxazole (TMP-SMX; one to two double-strength . Persistent, sometimes itchy, and painful bumps in your tattoo may be signs of an atypical mycobacterial infection. The average household teaspoon may not hold the right amount of liquid. ive missed three doses. High potassium levels: nausea, muscle cramps or weakness. Kosoglou T, Rocci ML Jr, Vlasses PH. Dieckmann R, Boone I, Brockmann SO, Hammerl JA, Kolb-Murer A, Goebeler M, Luch A, Al Dahouk S. Dtsch Arztebl Int. Having G6PD deficiency doesn't mean you can't take any medications. 1, pp. Hematologic changes indicative of folic acid deficiency may occur in elderly patients. You should not take Bactrim if you are pregnant or breastfeeding. Minor bumps and rashes can usually be managed at home with antibacterial ointment, proper cleaning, and rest. Drinking extra water will help to prevent some unwanted effects (eg, crystals in the urine). Evaluation for hyponatremia and appropriate correction is necessary in symptomatic patients to prevent life-threatening complications. There have been reports of marked but reversible nephrotoxicity with coadministration of BACTRIM and cyclosporine in renal transplant recipients. In two studies in rats, no teratology was observed when 512 mg/kg of sulfamethoxazole was used in combination with 128 mg/kg of trimethoprim. Drink plenty of fluids to prevent kidney stones. The estimated background risk of major birth defects and miscarriages for the indicated population is unknown. Call your doctor for medical advice about side effects. Our website is not intended to be a substitute for professional medical advice, diagnosis, or treatment. The mean renal clearance of trimethoprim was significantly lower in geriatric subjects compared with young adult subjects (19 mL/h/kg vs. 55 mL/h/kg). Click here for an email preview. The good news? This is one of the major risks you should be aware of before getting a new piercing or tattoo. Brumfitt W, Pursell R. Trimethoprim/Sulfamethoxazole in the Treatment of Bacteriuria in Women. No adverse effects on fertility or general reproductive performance were observed in rats given oral dosages as high as 350 mg/kg/day sulfamethoxazole plus 70 mg/kg/day trimethoprim, doses roughly two times the recommended human daily dose on a body surface area basis.